Vial Filling and Freeze-Drying Line liquid filling line
Grenzach-Wyhlen
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Seller's contacts
Germany 
Germany, Grenzach-Wyhlen
Germany, Burgwald-Ernsthausen
Germany, Menslage
Germany, Wentorf Bei Hamburg
Germany, Menslage
Germany, Menslage
Germany, Burgwald-Ernsthausen
Germany, Burgwald-Ernsthausen
Germany, Gräfelfing
Germany, Menslage
Uzbekistan, Tashkent
Italy, Castel San Pietro Terme (BO)
Netherlands, Emmeloord
France, Janville
Spain, Barcelona
Moldova, rl. Ocnita
Spain
Compressed air system with conditioning: Kaeser
Destillation and 10 m³ tank: Pharmatec
Freeze dryer: 3 systems
* H₂O₂-Generator: Steris M 1000-S
Lyophilizer: 3 systems
Primary container: Vials
* Product assignment according to provider: Pantoprazole
* Semi-automatic inspection machines: 4 systems
Small parts washing machine: Belimed PH820-2T, Identifier 14986
Weighing cabinet and LF units: White Pharmaceutical Technology
Description of the plant
Comprehensive pharmaceutical production equipment for the manufacture and processing of Pantoprazole in vials, consisting of process technology, vial cleaning, depyrogenation, filling, lyophilization and crimp sealing.
The central process line combines systems from IMA, HOF Special Plant Construction and Motus. For the preparation of the workpiece three 200-liter approach tanks from Gross Container Construction available. The vials are supplied via a IMA Hydra 1500 cleaned and subsequently a IMA Blue Galaxy 1250 endotoxin deactivation tunnel supplied.
The further processing is performed via the IMA F2000 filling system, a IMA V600 Trayloader and a Motus/HOF loading and unloading systemThe equipment inventory includes three HOF Freeze dryers as shown in the photos IMA ALU 600 crimping machine.
The equipment is complemented by autoclaves, cleaning technology, an H₂O₂ lock with generator, weighing and air guidance technology as well as systems for optical vial inspection.
Condition: Used, installed pharmaceutical production facilities. The photos show the systems in their existing production environment.
The exact delivery scope including connection technology, controls, format parts and supply systems is contractually defined based on the inventory list.
Scope of supply includes the components visible in the pictures.
General functions
- Preparation of dosing in three 200-liter kettles
- Cleaning of vials and subsequent depyrogenation
- Filling into vials
- Tray handling and loading of the freeze dryers
- Freeze-drying across three HOF systems
- Flange seal and downstream optical inspection
- Cleanup and sterilization of production components
The combination of vial washing, depyrogenation, filling and freeze-drying corresponds to an established process sequence for pharmaceutical vial lines.
Main components of the pantoprazol line
Area equipment according to asset list setup preparation 3 × large container construction, each 200 liters Boiler cleaning Hecht boiler cleaning machine Vial washing IMA Hydra 1500, identifier LX9006 Pyrogenation IMA Blue Galaxy 1250 / Libra, identifier LN8002 Filling IMA F2000, identifier SH1001 Tray handling IMA V600, identifier SA4001 Loading and unloading Motus/HOF, identifier ASC003 Freeze drying 3 × HOF, identifiers COM 21008, COM 21007 and COM 22001 Bellows seal IMA ALU; visible in photos as ALU 600 Optical control 4 × Seidenader/Körber V90-AVSB/75 as well as gate table
Additional pharmaceutical and supply technology
Also included in the listed plant inventory are:
- H₂O₂ lock Optima / Metal+Plastic, designation 30/535-000
- H₂O₂-Generator: Steris M 1000-S
- Autoclave: SBM SDT-13.10.15/2, Identifier FA 3120
- Autoclave: Belimed PST 6050/6060, additional designations per inventory list
- Small parts washing machine: Belimed PH820-2T, Identifier 14986
- Weighing cabin and LF units: Weiss Pharmatechnik
- Distillation and 10 m³ tank: Pharmatec
- Compressed air system with conditioning: Kaeser
- Refrigeration technology: 2 Combitherm systems and 3 Lauda devices
- Air treatment: IMA, Optima / Metal+Plastic and NOVA
The technical integration and the mapping of shared utility facilities are coordinated based on the plant documentation.
Further production areas according to the overall statement
The inventory list additionally includes standalone fittings/equipment for other pharmaceutical products:
AreaKey plant process and approach technology Symex CMF 2500 EX, CMF 5000 EX and CMF 500; Diesel process and approach vessels; large lye charging vesselsAdditional vessels Pfaudler E 3000 Policresulen kettle and plastic tanks from Jäger Kunststofftechnik Suppository production Sarong SAAS / 15AP and SAAS / 6AP Suppository packaging Tamponcolor TC120-150QT/Servo, IWK CP80R, Garvens/Mettler Toledo C3570 Ointment and tube line IWK TZ 101, TZK 100, TFS 20 and CPR; Garvens/Mettler Toledo XS2 Labeling and end packaging 2 × Neri BL-415 A, 2 × Markem-Imaje 2000 and Oli Collective packer
The inclusion of these additional production areas in the sales offer is made after the overall scope is defined.
Technical specifications
- Product assignment according to supplier: Pantoprazol
- Primary container: Vials
- Approach/receiving container: 3 × 200 liters
- Freeze dryer: 3 installations
- Semi-automatic inspection machines: 4 installations
- Total list: 56 positions, some with multiple individual devices
- Year of construction, line capacity, fill volume and vial formats: After supplementary documents
- Clearing spaces and condenser capacities of freeze dryers: After supplementary documents
Availability
Availability, inspection and handover by arrangement. Dismantling, loading, transport and the exact scope of documentation will be agreed on a project basis.
International shipping and export support can be arranged upon request.
Interested in this production line?
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